International Journal of Critical Illness and Injury Science

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 3  |  Page : 134--141

Use of heart rate variability to predict hospital length of stay for COVID-19 patients: A prospective observational study


Fateme Khodadadi1, Sujata Punait2, Jacek Kolacz4, Farid Zand3, Ali Foroutan4, Gregory F Lewis2 
1 Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
2 Intelligent Systems Engineering, Indiana University, The Traumatic Stress Research Consortium at the Kinsey Institute, Indiana University, Bloomington, Indiana
3 Department of Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4 Shiraz Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Dr. Gregory F Lewis
929 S. Brumley Ct. Bloomington,
Indiana

Background: As the COVID-19 pandemic continues, determining hospital demands has become a vital priority. Heart rate variability (HRV) has been linked to both the presence of viral infection and its severity. We investigate the possibility of using HRV parameters in comparison to other clinical parameters for predicting the hospital length of stay (LOS) for COVID-19 patients. Methods: This was a population-based cohort study. Measurements were performed in a specialized hospital for respiratory disease, dedicated to COVID-19. Patients were polymerase chain reaction positive for COVID-19 and on their 1st day of admission. Heart period, respiratory sinus arrhythmia (RSA), low frequency (LF) HRV, and vagal efficiency were calculated from electrocardiogram signals. This study investigated the correlation of HRV, demographic, and laboratory parameters with hospital LOS. Results: Forty-one participants were recruited, with a significant relationship, observed between hospital LOS and some demographic and clinical parameters such as lymphocyte count, age, and oxygen saturation of arterial blood. There was a negative relationship between LF and hospital LOS (r = −0.53, 95% confidence interval: −0.73, −0.24). Higher vagal efficiency predicted shorter hospital LOS in patients younger than 40 years of age (19.27% shorter hospital LOS was associated with a one SD higher value of VE, P = 0.007). Conclusion: HRV measurement is a non-invasive, inexpensive, and scalable procedure that produces several metrics, some of which are useful for predicting hospital LOS and managing treatment resources during COVID-19 pandemic.


How to cite this article:
Khodadadi F, Punait S, Kolacz J, Zand F, Foroutan A, Lewis GF. Use of heart rate variability to predict hospital length of stay for COVID-19 patients: A prospective observational study.Int J Crit Illn Inj Sci 2021;11:134-141


How to cite this URL:
Khodadadi F, Punait S, Kolacz J, Zand F, Foroutan A, Lewis GF. Use of heart rate variability to predict hospital length of stay for COVID-19 patients: A prospective observational study. Int J Crit Illn Inj Sci [serial online] 2021 [cited 2022 Jan 20 ];11:134-141
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2021;volume=11;issue=3;spage=134;epage=141;aulast=Khodadadi;type=0