International Journal of Critical Illness and Injury Science

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 3  |  Page : 123--133

Acute kidney injury in ventilated patients with coronavirus disease-2019 pneumonia: A single-center retrospective study


Mohamed Hamed Elkholi1, Zeyad Faoor Alrais1, Abdallah Reda Algouhary2, Muthana Salim Al-Taie1, Amr Abass Sawwan1, Abdelnasser Ahmed Khalafalla1, Maged Mohsen Beniamein1, Adel Elsaid Alkhouly1, Mohamed Ibrahim Shoaib1, Hesham Elsaid Alkholy1, Ammar Mohamed Abdel Hadi1, Ahmed Tarek Abu Alkhair1 
1 Department of Intensive Care, Rashid Hospital, Dubai, UAE
2 Department of Anesthesia, Rashid Hospital, Dubai, UAE

Correspondence Address:
Dr. Mohamed Hamed Elkholi
Department of Intensive Care, Rashid Hospital, 4545 Dubai
UAE

Background: Acute kidney injury (AKI) is repeatedly observed in ventilated critically ill patients with coronavirus disease-2019 (COVID-19) pneumonia. This study aimed to determine the incidence, risk factors, and consequences of AKI in the ventilated critically ill adult patients with COVID-19 pneumonia. Methods: This retrospective study included all the ventilated critically ill adult patients with COVID-19 pneumonia from March 1, 2020, to June 1, 2020. Data were collected from the electronic medical system. AKI was diagnosed using the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice definition. Patients were followed 90 days from the intensive care unit (ICU) admission time or to the date when they were discharged from the hospital. Results: AKI occurred in 65.1% of patients, with 26.6% of these started on continuous renal replacement therapy (CRRT). Patients with AKI had higher comorbidity and illness severity scores (P < 0.001). Age and the vasopressor requirements were predictors of AKI (P= 0.016 and P = 0.041) and hypertension predicted AKI (P = 0.099) and its progression (P = 0.05). The renal recovery rate was 86.7% and was associated with the mean arterial pressure on ICU admission in the no-CRRT group (P = 0.014) and the hypoxic index in the CRRT group (P = 0.019). AKI was associated with higher mortality (P = 0.017) and significantly longer ICU length-of-stay (P = 0.001). Additionally, AKI patients were more often discharged to a long-term skilled nursing facility (P = 0.005). Conclusion: COVID-19-associated AKI was common and associated with poor outcome, with the specific mechanisms being the main driving factors.


How to cite this article:
Elkholi MH, Alrais ZF, Algouhary AR, Al-Taie MS, Sawwan AA, Khalafalla AA, Beniamein MM, Alkhouly AE, Shoaib MI, Alkholy HE, Abdel Hadi AM, Abu Alkhair AT. Acute kidney injury in ventilated patients with coronavirus disease-2019 pneumonia: A single-center retrospective study.Int J Crit Illn Inj Sci 2021;11:123-133


How to cite this URL:
Elkholi MH, Alrais ZF, Algouhary AR, Al-Taie MS, Sawwan AA, Khalafalla AA, Beniamein MM, Alkhouly AE, Shoaib MI, Alkholy HE, Abdel Hadi AM, Abu Alkhair AT. Acute kidney injury in ventilated patients with coronavirus disease-2019 pneumonia: A single-center retrospective study. Int J Crit Illn Inj Sci [serial online] 2021 [cited 2021 Nov 28 ];11:123-133
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2021;volume=11;issue=3;spage=123;epage=133;aulast=Elkholi;type=0