International Journal of Critical Illness and Injury Science

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 3  |  Page : 117--122

Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study


Antonius Hocky Pudjiadi, Dwi Lestari Pramesti, Sudung O Pardede, Mulyadi M Djer, Rinawati Rohsiswatmo, Nastiti Kaswandani 
 Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia

Correspondence Address:
Dr. Antonius Hocky Pudjiadi
Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jl, Salemba Raya No. 6, Jakarta Pusat 10430
Indonesia

Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients. Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point. Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 (P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively. Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock.


How to cite this article:
Pudjiadi AH, Pramesti DL, Pardede SO, Djer MM, Rohsiswatmo R, Kaswandani N. Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study.Int J Crit Illn Inj Sci 2021;11:117-122


How to cite this URL:
Pudjiadi AH, Pramesti DL, Pardede SO, Djer MM, Rohsiswatmo R, Kaswandani N. Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study. Int J Crit Illn Inj Sci [serial online] 2021 [cited 2021 Dec 5 ];11:117-122
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2021;volume=11;issue=3;spage=117;epage=122;aulast=Pudjiadi;type=0