International Journal of Critical Illness and Injury Science

CASE REPORT
Year
: 2011  |  Volume : 1  |  Issue : 1  |  Page : 84--86

Propofol infusion syndrome in a super morbidly obese patient (BMI = 75)


Ramesh Ramaiah, Loreto Lollo, Douglas Brannan, Sanjay M Bhananker 
 Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA

Correspondence Address:
Ramesh Ramaiah
Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA
USA

Propofol infusion syndrome (PRIS) is a rare but often fatal complication as a result of large doses of propofol infusion (4-5 mg/kg/hr) for a prolonged period (>48 h). It has been reported in both children and adults. Besides large doses of propofol infusion, the risk factors include young age, acute neurological injury, low carbohydrate and high fat intake, exogenous administration of corticosteroid and catecholamine, critical illness, and inborn errors of mitochondrial fatty acid oxidation. PRIS manifestation include presence of metabolic acidosis with a base deficit of more than 10 mmol/l at least on one occasion, rhabdomyolysis or myoglobinuria, acute renal failure, sudden onset of bradycardia resistant to treatment, myocardial failure, and lipemic plasma. The pathophysiology of PRIS may be either direct mitochondrial respiratory chain inhibition or impaired mitochondrial fatty acid metabolism mediated by propofol. We report a case of supermorbidly obese patient who received propofol infusion by total body weight instead of actual body weight and developed PRIS.


How to cite this article:
Ramaiah R, Lollo L, Brannan D, Bhananker SM. Propofol infusion syndrome in a super morbidly obese patient (BMI = 75).Int J Crit Illn Inj Sci 2011;1:84-86


How to cite this URL:
Ramaiah R, Lollo L, Brannan D, Bhananker SM. Propofol infusion syndrome in a super morbidly obese patient (BMI = 75). Int J Crit Illn Inj Sci [serial online] 2011 [cited 2023 Jan 29 ];1:84-86
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2011;volume=1;issue=1;spage=84;epage=86;aulast=Ramaiah;type=0