Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 135


Home  | About Us | Editors | Search | Ahead Of Print | Current Issue | Archives | Submit Article | Instructions | Subscribe | Contacts | Login 
Year : 2022  |  Volume : 12  |  Issue : 4  |  Page : 211-216

Prognosis and sequelae of severe COVID-19 patients after 6 months of hospital discharge: A retrospective cohort study

Emergency and Critical Care Center, Kishiwada Tokusyukai Hospital, Osaka, Japan

Correspondence Address:
Dr. Daiki Shirasu
15-12-401 Harukiwakamatsu-cho, Kishiwada-City, Osaka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijciis.ijciis_38_22

Rights and Permissions

Background: We investigated the prognosis, sequelae, and related factors of severe coronavirus disease (COVID-19) patients who required invasive mechanical ventilation 6 months after discharge from the hospital. Methods: COVID-19 patients admitted to Kishiwada Tokusyukai Hospital between April 1, 2020, and May 31, 2021, and treated with an invasive mechanical ventilator were included in this study. We conducted a telephone visit 6 months after discharge to confirm survival and asked questions about sequelae. Results: The mortality rate 6 months after discharge was 7.4%. Tracheostomy (odds ratio [OR], 0.03; 95% confidence interval [CI], 0.003–0.26), high Acute Physiology and Chronic Health Evaluation II score (16.0 [interquartile range [IQR], 11.5–17.2] vs. 11.0 [IQR, 8.0–14.0]), prolonged hospital stay (17.0 [IQR, 12.7–24.5] vs. 10.0 [IQR, 8.0–13.0]), and prolonged ventilation duration (12.5 [IQR, 10.7–20.0] vs. 8.0 [IQR, 6.0–11.0]) were associated with the risk of death. Moreover, 49% of the patients had residual disability. The most common sequelae were hoarseness, respiratory distress on exertion (31% of symptomatic patients), and muscle weakness (22%). The prone positioning therapy (OR, 5.55; 95% CI, 1.35–32.97) was associated with hoarseness, and the use of muscle relaxants (OR, infinity; 95% CI, 1.14–infinity) was a risk factor for muscle weakness. Conclusion: Although the mortality rate after the acute phase of COVID-19 was not high, many patients experienced sequelae. Careful treatment should be continued after the end of acute treatment for patients with prolonged respiratory failure due to COVID-19. Muscle relaxants and prone positioning therapy may cause sequelae and should be performed carefully.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded12    
    Comments [Add]    

Recommend this journal