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Year : 2022  |  Volume : 12  |  Issue : 3  |  Page : 174-176

Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis: A case report

1 Department of Pathology, St. Luke's University Health Network, Bethlehem, PA, USA
2 Department of Gastroenterology, St. Luke's University Health Network, Bethlehem, PA, USA
3 Division of Internal Medicine, School of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
4 Department of Cardiology, St. Luke's University Health Network, Bethlehem, PA, USA

Correspondence Address:
Dr. Sudip Nanda
Department of Cardiology, St. Luke's Hospital, 801 Ostrum Street, Bethlehem, PA 18015
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijciis.ijciis_105_21

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Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tissues such as the gastrointestinal tract. These features have only been reported in patients treated with high doses. We report a patient who experienced acute colchicine toxicity with gastrointestinal histologic changes after treatment with the lowest dose of colchicine. Knowledge of drug–drug interactions and the organs involved in colchicine metabolism is imperative when using colchicine, even when administered at its lowest dose.

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