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REVIEW ARTICLE
Year : 2021  |  Volume : 11  |  Issue : 3  |  Page : 167-176

Pathogenesis and therapy of arteriovenous malformations: A case report and narrative review


1 Lewis Katz School of Medicine, Temple University, Philadelphia, USA
2 Department of Pulmonary and Critical Care, St. Luke's University Health Network, Bethlehem, PA, USA
3 Department of Pathology, St. Luke's University Health Network, Bethlehem, PA, USA
4 Department of Cardiology, St. Luke's University Health Network, Bethlehem, PA, USA

Correspondence Address:
Dr. Sudip Nanda
Department of Cardiology, St. Luke's University Health Network, Bethlehem, Pennsylvania
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJCIIS.IJCIIS_127_20

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Arteriovenous malformations (AVMs) are abnormal communications between arteries and veins that lack intervening capillary beds. They have been described in almost every organ in the body, emerging sporadically or as part of well-described syndromes. Hereditary hemorrhagic telangiectasia (HHT) is a rare, progressive, and lifelong disease characterized by AVMs and recurrent hemorrhaging. In the last 2 decades, significant advances have been made in understanding the pathogenesis of this condition. The accumulation of knowledge has led to a natural evolution of therapy, from open surgery to endovascular procedures, and now to a role for medications in certain AVMs. Here, we review a case of HHT and describe the most up-to-date clinical practice, including diagnosis of HHT, subtypes of HHT, and medical therapy.


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