Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 629

 

Home  | About Us | Editors | Search | Ahead Of Print | Current Issue | Archives | Submit Article | Instructions | Subscribe | Contacts | Login 
     


 
 
Table of Contents
LETTER TO THE EDITOR
Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 51

Gamma-hydroxybutyrate and keratinocytes proliferation (correspondence to Int J Crit Illn Inj Sci 2014;2:108-13)


1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Hainan, China

Date of Web Publication24-Feb-2016

Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok
Thailand
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5151.177364

Rights and Permissions

How to cite this article:
Joob B, Wiwanitkit V. Gamma-hydroxybutyrate and keratinocytes proliferation (correspondence to Int J Crit Illn Inj Sci 2014;2:108-13). Int J Crit Illn Inj Sci 2016;6:51

How to cite this URL:
Joob B, Wiwanitkit V. Gamma-hydroxybutyrate and keratinocytes proliferation (correspondence to Int J Crit Illn Inj Sci 2014;2:108-13). Int J Crit Illn Inj Sci [serial online] 2016 [cited 2022 Jul 3];6:51. Available from: https://www.ijciis.org/text.asp?2016/6/1/51/177364

Dear Editor,

A recent report on “gamma-hydroxybutyrate (GHB) and keratinocytes proliferation”[1] is very interesting. Rousseau et al., assessed the “effects of GHB sedation on keratinocytes proliferation”[1] and noted “a positive effect of GHB on keratinocyte proliferation”.[1] Murphy et al., previously mentioned for the possible effect of GHB on growth hormone system and mentioned its usefulness in wound healing.[2] To apply GHB use in injury science is interesting, however, the possible adverse effect of GHB should be mentioned. As noted by Brennan et al., “rising abuse of the drug is associated with dependence, withdrawal, acute toxicity, and fatal overdose”.[3] Hence, it is needed to weight between advantage and disadvantage of GHB for clinical use.

In addition, the concentration of GHB from laboratory analysis is another issue to be discussed. The endogenous GHB production is possible,[4] and this has to be kept in mind during interpretation of GHB level. Rousseau et al., should also mention and discuss about this important interference in laboratory analysis.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Rousseau AF, Bargues L, Bever HL, Vest P, Cavalier E, Ledoux D, et al. Effect of gamma-hydroxybutyrate on keratinocytes proliferation: A preliminary prospective controlled study in severe burn patients. Int J Crit Illn Inj Sci 2014;2:108-13.  Back to cited text no. 1
    
2.
Murphy KD, Rose MW, Chinkes DL, Meyer WJ 3rd, Herndon DN, Hawkins HK, et al. The effects of gammahydroxybutyrate on hypermetabolism and wound healing in a rat model of large thermal injury. J Trauma 2007;63:1099-107.  Back to cited text no. 2
    
3.
Brennan R, Van Hout MC. Gamma-hydroxybutyrate (GHB): A scoping review of pharmacology, toxicology, motives for use, and user groups. J Psychoactive Drugs 2014;46:243-51.  Back to cited text no. 3
    
4.
Busardò FP, Bertol E, Vaiano F, Baglio G, Montana A, Barbera N, et al. Post mortem concentrations of endogenous gamma hydroxybutyric acid (GHB) and in vitro formation in stored blood and urine samples. Forensic Sci Int 2014;243:144-8.  Back to cited text no. 4
    




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References

 Article Access Statistics
    Viewed1865    
    Printed44    
    Emailed0    
    PDF Downloaded52    
    Comments [Add]    

Recommend this journal