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Year : 2014  |  Volume : 4  |  Issue : 3  |  Page : 200-208

Academic college of emergency experts in India's indo-us joint working group and opus12 foundation consensus statement on creating a coordinated, multi-disciplinary, patient-centered, global point-of-care biomarker discovery network

1 Department of Research and Innovation, Research Institute, Bethlehem, Pennsylvania; OPUS 12 Foundation Global, Columbus, USA
2 Department of Research and Innovation; Research Institute, Bethlehem, Pennsylvania
3 Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India
4 Department of Anesthesiology, University of Toledo, College of Medicine, Toledo, USA
5 Department of Medicine, University College of Medical Sciences, New Delhi, India
6 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
7 OPUS 12 Foundation Global, Columbus, USA; Department of Surgery, St Luke's University Health Network, Bethlehem, Pennsylvania
8 OPUS 12 Foundation Global, Columbus; Department of Emergency Medicine, University of Florida and Winter Haven Hospital, Florida, USA
9 Department of Emergency Medicine, SUNY Downstate Medical Center, Long Island College Hospital, New York, USA
10 OPUS 12 Foundation Global, Columbus; Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA

Correspondence Address:
Stanislaw P Stawicki
Department of Research and Innovation, St Luke's University Health Network, 801 Ostrum Street, NW2 Administration, Bethlehem, Pennsylvania 18015

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5151.141398

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Biomarker science brings great promise to clinical medicine. This is especially true in the era of technology miniaturization, rapid dissemination of knowledge, and point-of-care (POC) implementation of novel diagnostics. Despite this tremendous progress, the journey from a candidate biomarker to a scientifically validated biomarker continues to be an arduous one. In addition to substantial financial resources, biomarker research requires considerable expertise and a multidisciplinary approach. Investigational designs must also be taken into account, with the randomized controlled trial remaining the "gold standard". The authors present a condensed overview of biomarker science and associated investigational methods, followed by specific examples from clinical areas where biomarker development and/or implementation resulted in tangible enhancements in patient care. This manuscript also serves as a call to arms for the establishment of a truly global, well-coordinated infrastructure dedicated to biomarker research and development, with focus on delivery of the latest discoveries directly to the patient via point-of-care technology.

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