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Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 17-20

Comparison of ketamine with fentanyl as co-induction in propofol anesthesia for short surgical procedures

1 Department of Anaesthesiology, Saraswati Institute of Medical Sciences, Hapur, Ghaziabad, Uttar Pradesh, India
2 Department of Anaesthesiology and Intensive Care, Govt. Medical College and Hospital, Sector 32, Chandigarh, India
3 Department of Anaesthesiology and Critical Care, UCMS and GTB Hospital, Dilshad Garden, Delhi, India

Correspondence Address:
Manpreet Singh
1219, Govt. Medical College and Hospital, Sec 32, Chandigarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5151.94890

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Background and Objective : A prospective randomized control study was conducted to compare and evaluate quality of anesthesia with ketamine or fentanyl as co-induction with propofol. Materials and Methods : Sixty ASA I or II, 18-50 year old patients who were scheduled for minor surgeries of short duration (<30 min anticipated duration) were selected. The patients were randomly allocated to group I and group II comprising 30 patients each. The patients of group I were given ketamine injection 0.5 mg/kg and group II patients fentanyl injection (1.5 μg/kg) as co-induction agent. Two minutes later, induction of anesthesia was given with inj propofol (2.5 mg/kg) and appropriate-sized laryngeal mask airway was inserted. The anesthesia was maintained with 60% N2 O in O 2 and intermittent bolus of inj propofol (0.5 mg/kg) after observing significant changes in the heart rate, blood pressure, lacrimation, sweating, and abnormal movements. Results: There was significant decrease (P<0.05) in the pulse rate, systolic and diastolic blood pressure at 1, 3, and 5 min in group II (fentanyl group) whereas the change was insignificant (P>0.05) at 10 min. Conclusion : It was observed that ketamine as premedicant was better than fentanyl with respect to hemodynamic stability and caused less adverse effects intraoperatively and postoperatively.

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