Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 647

 

Home  | About Us | Editors | Search | Ahead Of Print | Current Issue | Archives | Submit Article | Instructions | Subscribe | Contacts | Login 
     
ORIGINAL ARTICLE
Year : 2016  |  Volume : 6  |  Issue : 4  |  Page : 167-171

Comparison of the hemostatic effects of oxidized cellulose and calcium alginate in an experimental animal model of hepatic parenchymal bleeding


1 Department of Pediatric Surgery, Harran University Medical School, Şanlıurfa, Turkey
2 Department of Pediatric Surgery, Acıbadem Hospital, Kayseri, Turkey
3 Department of Pediatric Surgery, Erciyes University Medical School, Kayseri, Turkey
4 Department of Pathology, Erciyes University Medical School, Kayseri, Turkey

Correspondence Address:
Mustafa Erman Dorterler
Department of Pediatric Surgery, Harran University, Şanlıurfa
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5151.195397

Rights and Permissions

Background: Despite all recent developments, bleeding is still one of the main causes of increasing morbidity and mortality following both trauma and elective hepatic surgery. The main goal of treatment is stop the bleeding immediately. In this study, the hemostatic and histopathological effects of Ankaferd blood stopper (ABS), oxidized cellulose (OC), and calcium alginate (CA) were compared in an experimental liver injury. Materials and Methods: Forty Wistar albino rats were randomly divided into four groups of ten animals each, receiving 0.9% NaCl, CA, OC, or ABS following liver resection. After 5 days, the samples from the resection site were acquired for histopathological evaluation. The efficacy of the agents was assessed using the hematocrit level and histopathological examination. Statistical analyses were applied. Results: The amount of bleeding was lowest in ABS-treated rats, followed by those treated with OC, CA, and NaCl, respectively. The difference among the groups was statistically significant (P < 0.001). ABS-treated rats also had significantly less necrosis than those receiving OC; other differences in this regard were not significant. Inflammatory status was significantly different between OC- and CA-treated rats (P < 0.05) but not among the other groups (P > 0.05). No significant difference was determined between the groups regarding granulation (P > 0.05). Conclusion : ABS reduced the volume of bleeding in liver surgery and partial liver resection. The hemostatic effect of CA was limited.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed434    
    Printed5    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal